Nesosteine: a new mucoregulatory agent
Scuri, R.; Mondani, P.; Frova, C.; Fantini, L.
Drugs under Experimental and Clinical Research 12(8): 663-670
1986
ISSN/ISBN: 0378-6501 PMID: 3757762 Document Number: 272810
A new, original molecule, nesosteine, modified both the rheology and the production of tracheobronchial mucus in rabbits. The drug highly significantly reduced the viscosity of tracheobronchial mucus in animals made bronchitis by H2SO4 aerosol and markedly increased mucoproduction in healthy animals. Nesosteine was more active than the best known mucolytic/mucoregulatory drugs, such as sobrerol, N-acetylcysteine, bromexine, ambroxol, S-carboxymethylcysteine and mercaptopropionylglycine. The fluidifying activity of the drug was also demonstrated in vitro (pig's gastric mucin), although this proved to be less marked than in vivo. Nesosteine reduced the amount of total proteins of the tracheobronchia mucus, acting on albumin, .alpha.1, .alpha.2, .beta. and .gamma. mucoproteins.