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Acquired immunodeficiency in a patient with hemophilia

Alkan, M.; Kuperman, O.; Goldstein, G.; Berginer, V.

Harefuah 111(3-4): 74-76

1986

ISSN/ISBN: 0017-7768
PMID: 3098652
Document Number: 272680
A 19-year-old man with classical hemophilia who received Factor VIII concentrate for four years developed fever, lymphadenopathy and hepatosplenomegaly. During nine months of follow-up, he developed several opportunistic infections, including sepsis due to Serratia. A neuropsychiatric syndrome consisting of aggressive behavior, dementia and stupor was followed by death. Immunological studies revealed impairment of cell-mediated immunity and a reversal of the helper-suppressor T-lymphocyte ratio. Postmortem examination did not show signs of the infections or malignant diseases described in the acquired immunodeficiency syndrome (AIDS).

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