Prevalence of BRCA1 expression in epithelial ovarian cancer: immunohistochemical study
Sirisabya, N.; Manchana, T.; Termrungreunglert, W.; Triratanachat, S.; Charuruks, N.; Tresukosol, D.
Journal of the Medical Association of Thailand 90(1): 9-14
2007
ISSN/ISBN: 0125-2208 PMID: 17621726 Document Number: 2726
The 99 formalin fixed paraffin-embedded ovarian tissue specimens of Epithelial Ovarian Cancer(EOC) patients treated at the Gynecologic Oncoloy Unit, King Chulalongkorn Memorial Hospital between January 1, 1996 and December 31, 1999, were immuno-stained with BRCA1 antibody using the immunohistochemical method According to the criteria for BRCA1 immunohistochemical evaluation (neoplastic nuclear staining more than 10%), 12 (12.1%) of the 99 specimens showed positive BRCA1 expression. No associated statistical significance between clinicopathological variables and BRCA1 expression was detected Survival analysis was performed in 87 patients who were followed-up for more than 6 months and recent status were available. During a median follow-up of 43 months, median survival time was 46 months (range 6-84 months). No association between BRCA1 expression and survival outcomes was found (Disease free survival and overall survival) in the presented patients.
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