Top Abstract Purchase Related
Home
>
Node
>
Subnode

Increased rate of de novo purine synthesis and its mechanism in regenerating rat liver

Itakura, M.; Maeda, N.; Tsuchiya, M.; Yamashita, K.

American Journal of Physiology 251(5 Pt 1): G585-G590

1986

ISSN/ISBN: 0002-9513
PMID: 2430469
Document Number: 272570
In regenerating rat liver at 12 h after a 70% hepatectomy, [14C]glycine incorporation to hepatic acid-soluble purines increased by 2.4-fold with a 26% increase of the mean rapidly miscible glycine pool size and its comparable turnover rate. Amidophosphoribosyltransferase (EC 2.4.2.14, ATase) activity increased 1.8-fold at 18 h and 5-phosphoribosyl-1-pyrophosphate (PRPP) concentration increased 3.0-fold at 12 h after surgery. Decreases in ATP and GTP concentrations of 13 and 15%, respectively, in regenerating rat liver at 12 h after surgery were counterbalanced by increased AMP and GMP concentrations of 13 and 44%, respectively, with comparable inhibitory potentials on ATase. These results suggest that an increased rate of de novo purine synthesis in regenerating rat liver is mediated by the increased ATase activity and PRPP concentrations.

Document emailed within 1 workday
Secure & encrypted payments

Itakura, M.; Tsuchiya, M.; Yamashita, K.; Oda, T. 1986: Malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) increases liver de novo purine synthesis and amidophosphoribosyltransferase activity Journal of Pharmacology and Experimental Therapeutics 237(3): 794-798
Schwarzmeier, J.; Moser, K. 1971: Purine de novo-synthesis in lymphocytes Verhandlungen der Deutschen Gesellschaft für Innere Medizin 77: 398-400
Ray, M.S.; Muggia, F.M.; Leichman, C.G.; Grunberg, S.M.; Nelson, R.L.; Dyke, R.W.; Moran, R.G. 1993: Phase I study of (6R)-5,10-dideazatetrahydrofolate: a folate antimetabolite inhibitory to de novo purine synthesis Journal of the National Cancer Institute 85(14): 1154-1159
Natsumeda, Y.; Prajda, N.; Donohue, J.P.; Glover, J.L.; Weber, G. 1984: Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues Cancer Research 44(6): 2475-2479
Jackson, R.C.; Lui, M.S.; Boritzki, T.J.; Morris, H.P.; Weber, G. 1980: Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats Cancer Research 40(4): 1286-1291
Sakamoto, T.; Shoji, T.; Yokomuro, K. 1991: Hematolymphoid system in the liver--restoring mechanism of hemopoiesis in the regenerating liver Nihon Geka Gakkai Zasshi 92(4): 428-440
Faktor, V.M. 1985: Urethane inhibition of DNA synthesis in the hepatocytes of the regenerating liver in mice Tsitologiia 27(10): 1145-1149
Kimura, F.; Miyazaki, M.; Suwa, T.; Hayashida, K.; Kakizaki, S.; Ito, H.; Kaiho, T. 1993: Hepatic protein synthesis in regenerating liver after partial hepatectomy Nihon Geka Gakkai Zasshi 94(12): 1263-1268
Baranov, V.N.; Engel'gardt, N.V.; Lazareva, M.N.; Gusev, A.I. 1982: Ultrastructural localization of synthesis of alpha-fetoprotein in regenerating mouse liver Biulleten' Eksperimental'noi Biologii i Meditsiny 93(1): 77-81
Rabes, H.M.; Iseler, G.; Czichos, S.; Tuczek, H.V. 1977: Synchronization of hepatocellular DNA synthesis in regenerating rat liver by continuous infusion of hydroxyurea Cancer Research 37(4): 1105-1111
Fausto, N.; Brandt, J.T.; Kesner, L. 1975: Possible interactions between the urea cycle and synthesis of pyrimidines and polyamines in regenerating liver Cancer Research 35(2): 397-404
Iakovlev, A.I. 1979: Hepatocyte dynamic reserve: the mechanism for the assurance of specialized functions in the regenerating liver Tsitologiia 21(11): 1243-1252
Polishchuk, A.M.; Miagkaia, T.T.; Gunderina, L.I. 1971: Rate of incorporation of H3-thymidine into diploid and tetraploid cell nuclei of rat regenerating liver throughout the S-period Tsitologiia 13(10): 1225-1232
Lindamood, C.; Bedell, M.A.; Billings, K.C.; Swenberg, J.A. 1982: Alkylation and de novo synthesis of liver cell DNA from C3H mice during continuous dimethylnitrosamine exposure Cancer Research 42(10): 4153-4157
Beliaeva, I.D. 1970: Mitotic cycle of cells of regenerating rat liver in RNA synthesis disturbed by actinomycin in the G1 period Biulleten' Eksperimental'noi Biologii i Meditsiny 69(3): 105-107
Beliaeva, I.D. 1974: Signifcance of ribosomal RNA synthesis throughout the S-period for DNA reduplication and completion of the mitotic cycle of regenerating rat liver cells Tsitologiia 16(7): 820-825
Strain, A.J.; Frazer, A.; Hill, D.J.; Milner, R.D. 1987: Transforming growth factor beta inhibits DNA synthesis in hepatocytes isolated from normal and regenerating rat liver Biochemical and Biophysical Research Communications 145(1): 436-442
Komar, V.E.; Nikitina, Z.S. 1972: Effect of x-ray irradiation on the capacity of nuclear information RNA from regenerating rat liver to stimulate protein synthesis in a cell-free system Voprosy Meditsinskoi Khimii 18(1): 81-84
Shavlovskiĭ, G.M.; Ksheminskaia, G.P. 1972: Role of purine biosynthesis de novo in the flavinogenesis of Candida guilliermondii Mikrobiologiia 41(2): 273-279
Baugnet-Mahieu, L.; Goutier, R.; Baes, C. 1971: Reutilization of tritiated thymidine and tritiated iododeoxyuridine for the synthesis of nuclear and mitochondrial DNA in regenerating rat liver Archives Internationales de Physiologie et de Biochimie 79(4): 819-820