Percutaneous absorption of 7, 10 14C-benzo[a]pyrene and 7, 12 14C-dimethylbenz[a]anthracene in mice
Sanders, C.L.; Skinner, C.; Gelman, R.A.
Journal of Environmental Pathology Toxicology and Oncology Official Organ of the International Society for Environmental Toxicology and Cancer 7(1-2): 25-34
1986
ISSN/ISBN: 0731-8898 PMID: 3098955 Document Number: 272539
The percutaneous penetration, tissue distribution and excretion of 14C-labeled benzoanthracene (DMBA) were studied in mice. Both BP and DMBA rapidly penetrated the skin and were excreted more in the feces than in the urine. The proportion of BP and DMBA absorbed was less with increasing applied dose due to apparent saturation of the uptake process. Uptake from the dorsal skin of the nose was similar to uptake from the dorsal nuchal skin.