Determination of the digoxin concentration in the blood plasma of patients with cardiopulmonary failure
Sidorova, L.D.; Arkhipova, G.F.; Kudelia, L.M.; Pavlova, I.P.
Farmakologiia i Toksikologiia 49(5): 22-25
1986
ISSN/ISBN: 0014-8318 PMID: 3770167 Document Number: 272335
Digoxin was used for 2-4 weeks in a combined treatment of 98 patients with cardiopulmonary insufficiency. Blood plasma digoxin concentration was measured in 65 patients. A clinical improvement accompanied with positive hemodynamic changes, an improvement of myocardial contractility, a decrease of pulmonary hypertension was observed in 88% of patients. The relationship between a clinical effect and the drug dose was found. Correlation between blood digoxin concentration, stage of circulatory insufficiency and toxic manifestations was revealed.