Proof of the effectiveness of a clotrimazole cream paste in acne vulgaris
Huber, H.P.; Nook, T.
Zeitschrift für Hautkrankheiten 61(5): 320-322
1986
ISSN/ISBN: 0301-0481 PMID: 2938349 Document Number: 272141
The efficacy of Clotrimazol cream paste containing a penetration enhancer in the treatment of acne vulgaris was objectified by investigating the sebum composition. Following treatment over three and six weeks, the ratio of triglyceride to free fatty acid significantly increased, which indicated an effective reduction of the lipase activity of Propionibacterium acnes within the sebaceous follicle.