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Red man syndrome: inadvertent administration of an excessive dose of rifampin to children in a day-care center

Bolan, G.; Laurie, R.E.; Broome, C.V.

Pediatrics 77(5): 633-635

1986

ISSN/ISBN: 0031-4005
PMID: 3486402
Document Number: 271915
A cluster of toxic reactions among children inadvertently given excessive doses of rifampin for chemoprophylaxis of invasive Haemophilus influenzae disease in a day-care center was investigated. In all 19 children, who received five times the therapeutic dose of rifampin, dramatic adverse reactions developed. A striking, "glowing" red discoloration of the skin and facial or periorbital edema were found to be the hallmarks of rifampin toxicity. These clinical signs of acute toxicity contrast sharply with the adverse side effects of rifampin reported with therapeutic doses.

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