T lymphocyte subpopulations in infectious mononucleosis
Casadei Maldini, M.; Beltrandi, E.; Bonfiglioli, M.; Barboni, P.
Bollettino della Societa Italiana di Biologia Sperimentale 62(3): 371-376
1986
ISSN/ISBN: 0037-8771 PMID: 3487338 Document Number: 271670
The T lymphocyte subpopulations of peripheral blood of acute mononucleosis infections have been studied with monoclonal antibodies. A helper to suppressor ratio Leu 3/Leu 2 (0,16-0,83) in the patients (as compared with 1-2,2 in the controls), clearly showed the imbalance between the T-lymphocyte subset. We found a considerable increase of lymphocyte populations coexpressing the double markers Leu 4/DR (5,8-56,8) versus 0,28-1,35 of normal subjects; this could be expression of the activation of T cells showing the phenotype of the mature thymocyte.