Penicillamine as an adjuvant to antimonial therapy, effect on electrocardiographic changes in dogs
Girgis, N.I.; Khayyal, M.T.; McConnell, E.; Norton, J.
East African Medical Journal 47(11): 576-581
1970
ISSN/ISBN: 0012-835X PMID: 5498991 Document Number: 27160
Intravenous injections of tartar emetic at 5 mg/kg body-weight daily for 4 days were given to 55 healthy dogs. Concomitant injections of 11 mg/kg penicillamine were given to 25 of the dogs. 26% of the dogs given tartar emetic alone died during or shortly after treatment, but the mortality of dogs receiving the combined treatment was only 8%. Changes in electrocardiographic pattern were observed in 90% of tartar emetic-treated dogs and in 55% of dogs treated with combined tartar emetic and penicillamine.