6-Sulphanilamidoindazole-induced arthritis in rats: substance effects and acute-phase reaction
Hirschelmann, R.; Schade, R.
International Journal of Tissue Reactions 8(6): 469-473
1986
ISSN/ISBN: 0250-0868 PMID: 2432028 Document Number: 271306
Arthritis induced by 6-sulfanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferroxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAl arthritis. C-reactive protein and ceruloplasmin are demonstrated to be acute-phase reactants also in 6-SAl arthritis, although on the whole the acute-phase reaction is relatively weak. The steroid dexamethasone and the nonsteroid benoxaprofen caused strong antiinflammatory activity at low doses. The data presented complete the picture of 6-SAl arthritis as a special inflammatory reaction in rats.