Vagally mediated regulation of renal function in conscious primates
Vatner, S.F.; Manders, W.T.; Knight, D.R.
American Journal of Physiology 250(4 Pt 2): H546-H549
1986
ISSN/ISBN: 0002-9513 PMID: 3963212 Document Number: 271126
The effects of vagal denervation (VD) were examined on responses of Na+ and water excretion to acute volume expansion (18 ml/kg of 6% dextran in saline) in six conscious rhesus monkeys with chronic sinoaortic denervation (SAD). After SAD, volume expansion increased mean arterial pressure (from 95 .+-. 6.6 to 119 .+-. 7.5 mmHg), right atrial pressure (from 1.3 .+-. 0.7 to 5.9 .+-. 1,8 mmHg), urine flow (from 0.08 .+-. 0.01 to 0.68 .+-. 0.20 ml/min), and Na+ excretion (from 1.30 .+-. 0.45 to 29.51 .+-. 10.40 .mu.eq/min). After VD, volume expansion increased mean arterial and right atrial pressures similarly, but induced significantly lower (P < 0.05) increases in urine flow (from 0.05 .+-. 0.01 to 0.19 .+-. 0.03 ml/min) and Na+ excretion (from 0.87 .+-. 0.27 to 11.50 .+-. 6.13 .mu.eq/min). Thus vagal mechanisms appear to play an important role in mediating excretion of Na+ and water in response to acute volume expansion in the conscious primate.