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Protein kinase activity and phosphorylation of endogenous proteins in the rat colonic mucosa during chemical carcinogenesis

Sultanov, V.K.; Dorofeev, G.I.; Ivashkin, V.T.; Romanov, V.V.; Vasil'ev, V.I.

Voprosy Onkologii 32(7): 52-56

1986

ISSN/ISBN: 0507-3758
PMID: 3739297
Document Number: 270940
Treatment with a single dose of 21 mg/kg, of 1,2-dimethylhydrazine was followed by a significant decrease in the level of cAMP-dependent protein kinase (histone kinase) in rats' large bowel mucosa after 72 hrs. However, its level returned to basal value after 2 weeks, with casein kinase level remaining unchanged. Both carcinogen--induced tumors of the large bowel and adjacent mucosa showed a drop in protein (mol. wt.-50 kdalton) was enhanced in tumor considerably.

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