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Changes in the content of fibrinogen and its high-molecular derivatives as affected by the physical training of ischemic heart disease patients

Dudaev, V.A.; Diukov, I.V.; Borodkin, V.V.

Terapevticheskii Arkhiv 58(12): 62-67

1986

ISSN/ISBN: 0040-3660
PMID: 3824217
Document Number: 270369
Two groups of male patients with CHD were examined. The first group (30 persons) was treated with a 30-day therapeutic course of physical training on a bicycle ergometer, the second group received nitrates of prolonged action and beta-blocking agents. Eleven healthy men receiving a course of physical training were entered into the control group. The content of fibrinogen, soluble fibrin and fibrinogen degradation products in the blood plasma was investigated prior to and after a therapeutic course. An analysis of the blood plasma protein spectrum was performed using gel-filtration on a chromatographic column as well as separate disk-electrophoresis of the blood plasma proteins and isolated fractions in polyacrylamide gel. Regular physical training of the CHD patients resulted in a significant decrease in the content of fibrinogen, soluble fibrin and fibrin degradation products in the blood that might be conducive to the improvement of microcirculation and hence to lessening the number of angina attacks in these patients.

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