Analysis of interleukin 1 mediated radioprotection
Manori, I.; Kushilevsky, A.; Weinstein, Y.
Clinical and Experimental Immunology 63(3): 526-532
1986
ISSN/ISBN: 0009-9104 PMID: 3486730 Document Number: 269099
The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in the addition of IL-1 and mitogen abrogated the radioprotective effect. Under the same conditions IL-2 containing supernatants were effective, suggesting that the dose modifying effect of IL-1 acts through induction of IL-2 elaboration. The results of the present study may be important in cases where it is necessary to restore depressed immune response resulting from irradiation accidents or radiotherapy.