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Inhibition of overall protein and RNA synthesis as a mechanism for the tunicamycin induced decrease in cytochrome P-450 in rat hepatocytes

Singh, Y.; Shirhatti, V.; Liu, C.T.; Davies, H.W.; Krishna, G.

Biochemistry International 13(2): 213-220

1986

ISSN/ISBN: 0158-5231
PMID: 2429661
Document Number: 267990
In rat hepatocytes maintained in culture, cytochrome P-450 and NADPH cytochrome c reductase activities were decreased by tunicamycin in a dose and time dependent fashion. The effect of tunicamycin was mainly due to inhibition of protein synthesis. Tunicamycin decreased L-[35S] methionine incorporation into many proteins, including a 52 kDa cytochrome P-450 isozyme. Tunicamycin also reduced RNA synthesis. These results indicate that tunicamycin decreased cytochrome P-450 levels in hepatocytes by inhibiting protein and RNA synthesis.

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De Vries, J.E. 1994: Inhibition of IL-4- and IL-13-induced IgE synthesis by an IL-4 mutant protein Arbeiten aus dem Paul-Ehrlich-Institut Zu Frankfurt A.M 87: 275-280; Discussion: 280-282
Higashi, K.; Tsukada, K.; Hoshino, M.; Nomura, T.; Takeuchi, T.; Hoek, J.B. 1994: Inhibition of ethanol-induced inositol phosphate formation and Ca(2+) mobilization by okadaic acid in rat hepatocytes: evidence for a role of protein phosphatases in the modulation of phospholipase C by ethanol Alcohol and Alcoholism . Suppl 29(1): 53-59
Pichard, L.; Fabre, J.M.; Domergue, J.; Fabre, G.; Saint-Aubert, B.; Mourad, G.; Maurel, P. 1991: Molecular mechanism of cyclosporine a drug interactions: inducers and inhibitors of cytochrome P450 screening in primary cultures of human hepatocytes Transplantation Proceedings 23(1 Part 2): 978-979
Ha, T.G.; Kim, N.D. 1998: 2-(allylthio)pyrazine inhibition of aflatoxin B1-induced hepatotoxicity in rats: inhibition of cytochrome P450 2B- and 3A2-mediated bioactivation Research Communications in Molecular Pathology and Pharmacology 102(1): 69-78
Kleihues, P.; Margison, J.M.; Margison, G.P. 1975: Dimethylnitrosamine-induced inhibition of hepatic protein synthesis in vitro and the effect of pretreatment with cystamine or pregnenolone-16alpha-carbonitrile Cancer Research 35(12): 3667-3672
Faktor, V.M. 1985: Urethane inhibition of DNA synthesis in the hepatocytes of the regenerating liver in mice Tsitologiia 27(10): 1145-1149
Kim, J.Y.; Baek, M.; Lee, S.; Kim, S.O.; Dong, M.S.; Kim, B.R.; Kim, D.H. 2001: Characterization of the selectivity and mechanism of cytochrome P450 inhibition by dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate Drug Metabolism and Disposition: the Biological Fate of Chemicals 29(12): 1555-1560
Winter, S.; Weller, M. 1998: Potentiation of CD95L-induced apoptosis of human malignant glioma cells by topotecan involves inhibition of RNA synthesis but not changes in CD95 or CD95L protein expression Journal of Pharmacology and Experimental Therapeutics 286(3): 1374-1382
Rieber, M.; Bacalao, J. 1974: Selective enhancement of cytoplasmic protein species and continued histone synthesis during inhibition of DNA synthesis in temperature-sensitive Chinese hamster cells Cancer Research 34(11): 3083-3088
Gutnikova, M.N.; Shevchenko, N.A.; Boĭkov, P.I.; Mitrokhin, I.I.; Todorov, I.N. 1985: Activation of nuclear polypeptide synthesis in rat liver cells after inhibition of template protein synthesis. the role of nuclear polypeptide synthesis in the changes of the chromatin structure Biokhimiia 50(12): 1990-1996
Wang, W.H.; Lu, M.; Hebert, S.C. 1996: Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL American Journal of Physiology 271(1 Pt 1): C103-C111
Furui, T.; Kurauchi, O.; Tanaka, M.; Mizutani, S.; Ozawa, T.; Tomoda, Y. 1994: Decrease in cytochrome c oxidase and cytochrome oxidase subunit I messenger RNA levels in preeclamptic pregnancies Obstetrics and Gynecology 84(2): 283-288
Leinweber, F.J.; Braun, G.A. 1970: Mechanism of inhibition of histamine synthesis in the rat: two specific gastric histidine decarboxylases Molecular Pharmacology 6(2): 146-155
Lillibridge, J.H.; Liang, B.H.; Kerr, B.M.; Webber, S.; Quart, B.; Shetty, B.V.; Lee, C.A. 1998: Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate Drug Metabolism and Disposition: the Biological Fate of Chemicals 26(7): 609-616
Swanborg, R.H. 1972: Antigen-induced inhibition of experimental allergic encephalomyelitis. I. Inhibition in guinea pigs injected with non-encephalitogenic modified myelin basic protein Journal of Immunology 109(3): 540-546
Sirica, A.E.; Hwang, C.G.; Sattler, G.L.; Pitot, H.C. 1980: Use of primary cultures of adult rat hepatocytes on collagen gel-nylon mesh to evaluate carcinogen-induced unscheduled DNA synthesis Cancer Research 40(9): 3259-3267
Sinal, C.J.; Bend, J.R. 1996: Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzyl-1-aminobenzotriazole and N-alpha-methylbenzyl-1-aminobenzotriazole Drug Metabolism and Disposition: the Biological Fate of Chemicals 24(9): 996-1001
Anukarahanonta, T.; Shinozuka, H.; Farber, E. 1973: Inhibition of protein synthesis in rat liver by D-galactosamine Research Communications in Chemical Pathology and Pharmacology 5(2): 481-491
Land, S.C.; Buck, L.T.; Hochachka, P.W. 1993: Response of protein synthesis to anoxia and recovery in anoxia-tolerant hepatocytes American Journal of Physiology 265(1 Pt 2): R41-R48
Tada, K.; Trakatellis, A.C. 1970: Mechanism of action of sparsomycin on protein synthesis Antimicrobial Agents and ChemoTherapy 10: 227-230