Minimizing between-kit variability in immunoassay for carcinoembryonic antigen by use of a common standard
Zucchelli, G.C.; Pilo, A.; Chiesa, M.R.; Masini, S.; Baccini, C.
Clinical Chemistry 32(10): 1942-1943
1986
ISSN/ISBN: 0009-9147 PMID: 3757215 Document Number: 267948
Between-laboratory agreement of CEA determinations collected in a multicenter study has been substantially improved (CV decreased from 60.4 to 21.6%) by converting the results from mass concentration units (ng/mL) of local kit standards to int. units/L of the international standard first IRP 73/601. Conversion factors for the kits most used were computed, during the same survey, from results of two analytical-recovery experiments in which control samples, supplemented with the international standard, were analyzed by participating laboratories (n = 96).