Physiological and molecular correlates of age-related changes in the human beta-adrenergic receptor system
Feldman, R.D.
Federation Proceedings 45(1): 48-50
1986
ISSN/ISBN: 0014-9446 PMID: 3000834 Document Number: 267877
Aging decreases hormone responsiveness in several receptor systems. In this article I consider both physiological and biochemical studies supporting the hypothesis that beta-adrenergic receptor responsiveness is reduced with aging in humans. Reduced chronotropic and vasodilator responses to the beta-receptor agonists isoproterenol and metaproterenol have been demonstrated. In human leukocytes a reduction in adenylate cyclase (EC 4.6.1.1) activity occurs with aging. More recently it has been suggested that this reduction in beta-adrenergic responsiveness with aging may be caused by an uncoupling of the beta receptor from the catalytic component.