Studies of the effects of heparin, Coumadin, and vitamin K on prothrombin metabolism and distribution in calves with the use of iodine-125-prothrombin. Characterization of the prothrombin system
Takeda, Y.
Journal of Laboratory and Clinical Medicine 75(3): 355-381
1970
ISSN/ISBN: 0022-2143 PMID: 4984660 Document Number: 26744
The metabolism of prothrombin in calves is described. The calculated rate of prothrombin synthesis was increased by vitamin K and inhibited by the antagonist Coumadin; it returned abruptly to the initial level as soon as plasma prothrombin concentration did so.
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