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Effect of hemosorption on the ultrastructure of hepatocytes in toxic liver damage

Kasymov, A.K.; Kasymov, S.Z.; Vorozheĭkin, V.M.; Kirichenko, I.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 99(3): 368-370

1985

ISSN/ISBN: 0365-9615
PMID: 3986354
Document Number: 266551
Extracorporeal perfusion of toxic blood via carbonic sorbents is an effective method for correcting severe disturbances of hemostasis. Ultrastructural alterations in hepatic cells were studied in experimental toxic liver injury before and after hemosorption. It was established that after hemosorption the processes of intracellular regeneration were significantly activated in the liver parenchyma. The number of crysts in the mitochondria increased as did the electronic density of the matrix. At the same time the number of lysosomes rose as well. However, in persistent unresolved cholestasis, destructive alterations in the hepatic tissue progressed despite the performance of hemosorption.

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