Potential obstetrical application of prostaglandins
Kunimoto, K.
Nihon Sanka Fujinka Gakkai Zasshi 37(12): 2857-2861
1985
ISSN/ISBN: 0300-9165 PMID: 3910743 Document Number: 266276
The potential obstetrical application of prostaglandins (PGs), in particular PG F2-alpha (PGF2a), PGE2, and PGE1 is discussed. Much of the research discussed is based upon experiments performed either on human females or on rats and sheep. Some important applications of PGs (particularly PGE2) are for inducing labor, regulating uterine contractions during delivery, and making uterine walls more flexible. PGE1 (or preglandin, as it is commercially known) is widely used to induce abortion in the intermediate stages and bring about uterine contractions. PGF2a can be used to stop bleeding caused by uterine relaxation and to treat puerperium bladder paralysis. PGE1 application for intrauterine growth retardation is also mentioned. PGs can also be used to treat patent ductus arteriosus. Some general methods for administering PGs are also discussed.