Comparison of the effects of nifedipine on ureter and coronary artery isolated from the dog
Sakanashi, M.; Kato, T.; Miyamoto, Y.; Takeo, S.; Noguchi, K.; Ito, H.; Nakasone, J.; Aniya, Y.
Arzneimittel-Forschung 35(3): 584-587
1985
ISSN/ISBN: 0004-4172 PMID: 4039584 Document Number: 265439
The effect of nifedipine (Adalat) on isolated dog ureter was compared with that on isolated coronary artery. Nifedipine at a concentration of 10(-8) mol/l significantly decreased the frequency of ureteral rhythmic contractions evoked by potassium, and suppressed the force of these contractions at a concentration of 3 X 10(-8) mol/l. In potassium-contracted coronary artery strips, nifedipine at concentrations more than 3 X 10(-9) mol/l produced significant relaxations in a concentration-dependent manner. The results indicate that nifedipine is able to act inhibitorily on ureteral contractions, and inhibition of pace making activities in ureteral smooth muscle was suggested as a mode of action of nifedipine.