Organ tolerance of non-steroidal anti-inflammatory drugs: effect on liver cells
Rossi, F.; Filippelli, W.; Guarino, V.; Russo, S.; Magliulo, R.; Marmo, E.
Drugs under Experimental and Clinical Research 11(8): 511-516
1985
ISSN/ISBN: 0378-6501 PMID: 3836872 Document Number: 263455
Experimental studies in mice and in rats showed the good tolerance of a new non-steroidal anti-inflammatory drug, flunoxaprofen, by normal and CCl4 damaged liver. The activity of an enzyme-inducing drug, such as phenobarbital, showed a greater increase after pretreatment with indomethacin than with flunoxaprofen or benoxaprofen. High doses of benoxaprofen and indomethacin significantly decreased bromosulphonphthalein excretion in rats with normal or CCl4 damaged liver; the effect was not observed with flunoxaprofen administered at the same dose as benoxaprofen. Moreover, benoxaprofen and indomethacin but not flunoxaprofen induced a significant increase of some serum liver enzymes in CCl4 poisoned rats.