Effect, toxicity and tissue concentration in the clinical use of cis-diamminedichloroplatinum (II)
Kodama, S.; Obata, N.; Hando, T.; Ikarashi, T.; Goto, A.; Takeuchi, S.
Nihon Sanka Fujinka Gakkai Zasshi 37(5): 683-690
1985
ISSN/ISBN: 0300-9165 PMID: 4039742 Document Number: 261821
The tissue cis-diamminedichloroplatinum (II) (CDDP) concentration was measured in autopsies treated with CDDP therapy for gynecological malignancies. These cases consisted of 10 of ovarian tumor and one of choriocarcinoma. Total CDDP doses administered were from 55mg to 560mg and among them three cases were treated with more than 500mg (525mg, 555mg in ovarian cancer and 560mg in choriocarcinoma). We found moderate renal impairment with this drug by serum functional test and histopathology, although these changes did not correspond with the total doses. In liver, kidney and residual tumor measured for CDDP, the tissue concentration was highest in liver. When total doses administered were compared with the tissue concentration in liver, kidney, residual tumor and the decrease in creatinine clearance value, there were statistically significant differences only in residual tumor at p less than 0.01.