Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats

Cross, C.E.; Warren, D.; Gerriets, J.E.; Wilson, D.W.; Halliwell, B.; Last, J.A.; Cross, C.E; Warren, D; Gerriets, J.E; Wilson, D.W; Halliwell, B; Last, J.A

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Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats

Cross, C.E.; Warren, D.; Gerriets, J.E.; Wilson, D.W.; Halliwell, B.; Last, J.A.

Journal of Laboratory and Clinical Medicine 106(4): 433-438

1985

ISSN/ISBN: 0022-2143

PMID: 2413151

Document Number: 261077

Bleomycin is an antineoplastic agent that causes a dose-related lung fibrosis that limits its therapeutic effectiveness. It has been proposed that the cellular toxicity and antitumor effects of bleomycin occur by formation of O2-Fe(II)-bleomycin complexes that degrade DNA and release O2- and OH radicals that attack other cellular components. Twice daily injections of the iron chelator deferoxamine were utilized in an attempt to ameliorate bleomycin-induced lung fibrosis. They failed to diminish bleomycin-induced lung inflammation and fibrosis in rats.