Effect of immunoglobulin prophylaxis on the incidence of the development of anicteric forms of hepatitis a
Gorbunov, M.A.; Sumarokov, A.A.; Ikoev, V.N.; Iaroshevskaia, I.I.; Kudriakova, R.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 10: 57-60
1985
ISSN/ISBN: 0372-9311 PMID: 2936044 Document Number: 260429
As the result of the clinico-biochemical examination of children in the foci of hepatitis A, carried out under the conditions of a strictly controlled epidemiological trial, the data on the frequency of the formation of the anicteric forms of hepatitis A in the course of the realization of different tactics of immunoglobulin prophylaxis have been established. The administration of immunoglobulin in a single injection has been shown to decrease the number of both manifest and anicteric forms of hepatitis A two times in comparison with the control. The administration of the preparation on contacts with hepatitis A patients in areas with a high morbidity level has been found to produce no decrease in the frequency of the manifest and anicteric forms of hepatitis A, this frequency remaining on the level registered in the control groups.