KAI1/CD82 gene expression in benign prostatic hyperplasia and late-stage prostate cancer in Chinese
Hu, W.L.; Li, Y.Q.; He, H.X.; Li, Q.R.; Tian, Y.; Lai, R.Q.; Mei, H.
Asian Journal of Andrology 2(3): 221-224
2000
ISSN/ISBN: 1008-682X PMID: 11225981 Document Number: 259292
To evaluate KAI1/CD82 expression in Chinese patients with benign prostatic hyperplasia (BPH) and late-stage carcinoma of prostate (CaP). Thirty Chinese patients with benign prostatic hyperplasia and 34 with CaP (adenocarcinoma clinical stage C and D) were analyzed by means of immunohistochemical methods. The KAI1/CD82 expression in BPH tissue was all positive, which was uniformly located on the glandular cell membrane at the cell-to-cell borders, but KAI1/CD82 expression in metastasis CaP tissues was either significantly lower than that of BPH or negative, and the immunostaining pattern was not continuous. In late-stage CaP KAI1/CD82 expression was correlated inversely to the pathological grade ( P < 0.05), but not to clinical stage ( P > 0.05). The authors believe that decreased and negative KAI1/CD82 expression in late-stage CaP may be related to tumor progression and metastasis, and appears to be a prognostic marker.