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Juvenile chronic arthritis. Double-blind study of the efficacy and tolerance of D-penicillamine

Prieur, A.M.; Piussan, C.; Manigne, P.; Bordigoni, P.; Griscelli, C.; Reinert, P.; de Goujon, F.; Lefur, J.M.; Garnier, J.M.

Archives Francaises de Pediatrie 42(2): 91-96

1985

ISSN/ISBN: 0003-9764
PMID: 3890795
Document Number: 259039
Seventy-four children with juvenile chronic arthritis were admitted to a 6-month multicentric double blind comparative study of the efficiency of D-Penicillamine or placebo. The results evaluated in 55 patients who completed the study, indicated an improvement in the total number of stiff joints and in the total index of severity measuring joint pain and inflammation. A significant reduction of the concurrent use of non steroidal antiinflammatory drugs was also observed. The tolerance was good except in two patients. Some children in the placebo group exhibited a definite improvement.

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