Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
Fang, G.; Kuiken, C.; Weiser, B.; Rowland-Jones, S.; Plummer, F.; Chen, C-Hsiung.; Kaul, R.; Anzala, A.Omu.; Bwayo, J.; Kimani, J.; Philpott, S.M.; Kitchen, C.; Sinsheimer, J.S.; Gaschen, B.; Lang, D.; Shi, B.; Kemal, K.Sherefa.; Rostron, T.; Brunner, C.; Beddows, S.; Sattenau, Q.; Paxinos, E.; Oyugi, J.; Burger, H.
Journal of Infectious Diseases 190(4): 697-701
2004
ISSN/ISBN: 0022-1899 PMID: 15272396 DOI: 10.1086/421504Document Number: 258458
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.