Cardiac effects of fenoterol hydrobromide on newborn versus adult rats
Kast, A.; Tsunenari, Y.; Honma, M.; Iida, H.
Arzneimittel-Forschung 35(1a): 188-192
1985
ISSN/ISBN: 0004-4172 PMID: 4039160 Document Number: 258237
The toxicity of fenoterol hydrobromide, a beta-adrenoceptor stimulant, was studied in newborn and adult SD-rats dosed with 0 (control), 2.5, 75 and 600 mg/kg/day by gavage for 35 days. 600 mg/kg was lethal for both age groups: newborn rats died either from gastro-intestinal disorders during the lactation period or from underweight and cachexia immediately after weaning. Adult rats which died from 600 mg/kg showed extended myocardial scars. No substance-related myocardial lesions were observed in newborn rats killed terminally, whereas adult rats had a dose-dependent increase in heart weights, at 600 mg/kg also extended myocardial scars.