Measurement of uteroplacental circulation with 113m indium in diabetic pregnancy
Semmler, K.; Kirsch, G.; Zöllner, P.; Fuhrmann, K.; Jutzi, E.
Zentralblatt für Gynakologie 107(13): 793-802
1985
ISSN/ISBN: 0044-4197 PMID: 4036401 Document Number: 257959
In 122 diabetic pregnancies the placental blood flow has been estimated determining the half life of the activity inflow (2 MBq 113 m In labelled transferrin) into the placental bed. We used a highly sensitive detector (modified pinhole collimator) and a computer supported evaluation, free from subjective influences. 259 flow measurements were compared to the risk of complication in the course of a diabetic pregnancy. - The half life values in the diabetic group, calculated by a gamma camera computer system by means of an iterative regression analysis, were significantly different compared to a control group (12 pregnancies without risk.) - Severe diabetic angiopathic complications (White classes D, F, and R) are accompanied by higher half life values (placental blood flow reductions) and perinatal complications. - Even in pregnant women with gestational diabetes or disturbances of the carbohydrate metabolism a disturbed placental hemodynamic is to be found.