Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
Shtivelman, E.; Lifshitz, B.; Gale, R.P.; Canaani, E.
Nature 315(6020): 550-554
1985
ISSN/ISBN: 0028-0836 PMID: 2989692 Document Number: 257308
Human chronic myelogenous leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22, and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8 kilobase RNA specific to chronic myelogenous leukemia shows it to be a fused transcript of the 2 genes. The fused protein that would be produced is probably involved in the malignant process.
Document emailed within 1 workday
Related Documents
Van Rhee, F.; Lin, F.; Cross, N.C.; Reid, C.D.; Lakhani, A.K.; Szydlo, R.M.; Goldman, J.M. 1994: Detection of residual leukaemia more than 10 years after allogeneic bone marrow transplantation for chronic myelogenous leukaemia Bone Marrow Transplantation 14(4): 609-612Wöhrer, S.; Rabitsch, W.; Shehata, M.; Kondo, R.; Esterbauer, H.; Streubel, B.; Sillaber, C.; Raderer, M.; Jaeger, U.; Zielinski, C.; Valent, P. 2007: Mesenchymal stem cells in patients with chronic myelogenous leukaemia or bi-phenotypic Ph+ acute leukaemia are not related to the leukaemic clone Anticancer Research 27(6b): 3837-3841
Martinelli, G.; Testoni, N.; Montefusco, V.; Amabile, M.; Saglio, G.; Ottaviani, E.; Terragna, C.; Bonifazzi, F.; de Vivo, A.; Pane, F.; Rosti, G.; Tura, S. 1998: Detection of bcr-abl transcript in chronic myelogenous leukemia patients by reverse-transcription-polymerase chain reaction and capillary electrophoresis Haematologica 83(7): 593-601
Lisiewicz, J.; Malkiewicz-Wasowicz, B.; Biernacka, B. 1973: Thromboplastic activity of chronic myelogenous leukaemia granulocytes Folia Haematologica 99(1): 57-64
Klener, P.; Donner, L. 1981: Hydroxyurea (Biosupressin-BIOGAL) for the treatment of chronic myelogenous leukaemia Therapia Hungarica 29(1): 38-41
Wu, H.K.; Heng, H.H.; Siderovski, D.P.; Dong, W.F.; Okuno, Y.; Shi, X.M.; Tsui, L.C.; Minden, M.D. 1996: Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1 Oncogene 12(6): 1205-1212
Garicochea, B.; Chase, A.; Lazaridou, A.; Goldman, J.M. 1994: T lymphocytes in chronic myelogenous leukaemia (CML): no evidence of the BCR/ABL fusion gene detected by fluorescence in situ hybridization in 14 patients Leukemia 8(7): 1197-1201
Maruyama, F.; Stass, S.A.; Estey, E.H.; Cork, A.; Hirano, M.; Ino, T.; Freireich, E.J.; Yang, P.; Chang, K.S. 1994: Detection of AML1/ETO fusion transcript as a tool for diagnosing t(8;21) positive acute myelogenous leukemia Leukemia 8(1): 40-45
Moravcova, J.; Regner, J.; Mouckova, D.; Fiser, K.; Zmekova, V.; Malacova, R.; Michalova, K.; Klamova, H. 2005: Disease status in patients with chronic myeloid leukemia is better characterized by BCR-ABL/BCR transcript ratio than by BCR-ABL transcript level, which may suggest a role of normal BCR gene in the disease pathogenesis Neoplasma 52(2): 119-125
Rozman, C.; Woessner, S. 1979: Chronic lymphosarcoma-cell leukaemia versus chronic lymphocytic leukaemia. Quantitative electron-microscopic study Sangre 24(4): 396-411
Melo, J.V.; Goldman, J.M. 1992: Specific point mutations that activate v-abl are not found in Philadelphia-negative chronic myeloid leukaemia, Philadelphia-negative acute lymphoblastic leukaemia or blast transformation of chronic myeloid leukaemia Leukemia 6(8): 786-790
Melo, J.V.; Myint, H.; Galton, D.A.; Goldman, J.M. 1994: P190BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia? Leukemia 8(1): 208-211
Uno, H.; Kawano, K.; Matsuoka, H.; Tsuda, K. 1988: HLA and adult T cell leukaemia: HLA-linked genes controlling susceptibility to human T cell leukaemia virus type i Clinical and Experimental Immunology 71(2): 211-216
Löwenberg, B. 1997: Treatment of acute myelogenous leukaemia Journal of Internal Medicine. Supplement 740: 17-22
Gorman, A.; Fennelly, J.J.; O'Connell, L.G. 1972: Intensive chemotherapy of acute myelogenous leukaemia Journal of the Irish Medical Association 65(20): 509-513
Jaiprakash, M.P.; Antia, P.K.; Shetty, P.A. 1981: Extramedullary deposits in acute myelogenous leukaemia Indian Journal of Cancer 18(1): 51-53
Monahan, B.P.; Rector, J.T.; Liu, P.P.; Cotelingam, J.D.; Dahut, W. 1996: Clinical aspects of expression of inversion 16 chromosomal fusion transcript CBFB/MYH11 in acute myelogenous leukemia subtype M1 with abnormal bone marrow eosinophilia Leukemia 10(10): 1653-1654
Quaglino, D.; Lusvarghi, E.; Piccinini, L.; di Prisco, A.U.; Guerzoni, O.; Mauri, C. 1976: The association between chronic lymphocytic leukaemia and a solid tumor: a survey study of 258 cases of chronic lymphocytic leukaemia covering an eleven year period Haematologica 61(4): 456-469
Ruvinskiĭ, A.O.; Agul'nik, A.I.; Protopopov, A.I.; Agul'nik, S.I.; Beliaev, D.K. 1987: Effect of t12 haplotype on the manifestation and inheritance of fused and kinky genes in house mice Genetika 23(1): 157-170
Cronn, R.C.; Adams, K.L. 2003: Quantitative analysis of transcript accumulation from genes duplicated by polyploidy using cDNA-SSCP Biotechniques 34(4): 726