Lymphocytes of haemophilia patients treated with clotting factor concentrates display activation-linked cell-surface antigens
Köller, U.; Majdic, O.; Liszka, K.; Stockinger, H.; Pabinger-Fasching, I.; Lechner, K.; Knapp, W.
Clinical and Experimental Immunology 59(3): 613-621
1985
ISSN/ISBN: 0009-9104 PMID: 3921299 Document Number: 256847
Peripheral blood lymphocytes from 30 patients with hemophilia A were investigated for the expression of 6 activation-linked cell surface antigens as well as with regard to the relative proportions and total numbers of Leu-3a and Leu-2a positive cells. Of the hemophilia patients 29 showed no clinical symptoms of immunodeficiency or infection; 1 patient presented the typical symptomatology of the acquried immunodeficiency syndrome (AIDS). The proportions and total number of circulating lymphocytes displaying Ia antigens, the p45 protein and/or the 2 recently defined surface antigens, VIP-4 and VIP-5, were significantly increased in hemophilia patients when compared to healthy individuals of the same age group. No such increases could be observed for transferrin receptor and IL-2 receptor expression. After the observation of depressed helper/suppressor T-cell ratios in many hemophiliacs, the expression of activation-linked surface antigens represents a further lymphocyte abnormality which resembles the findings in AIDS and its prodromal stages, and can also be found in certain viral and parasitic diseases.