New morphological aspects of pathogenesis of pneumofibrosis in anthracosis
Shkutin, A.E.
Arkhiv Patologii 47(6): 80-84
1985
ISSN/ISBN: 0004-1955 PMID: 3901975 Document Number: 256474
The death of the alveolar macrophage stimulating the activation of fibroblast in pneumoconiosis is not a single trigger mechanism of pneumofibrosis in anthracosis. Alteration of the microcirculatory bed and lung aerohematic barrier plays an essential pathogenetic role in coal pneumoconiosis. Polycarbonic acids which are formed in the organism from coal as a result of its oxidative-hydrolytic degradation are the cause of the damage and loss of the structural components of the aerohematic barrier.