Depressed classical complement pathway activities in chronic lymphocytic leukaemia
Füst, G.; Czink, E.; Minh, D.; Miszlay, Z.; Varga, L.; Hollán, S.R.
Clinical and Experimental Immunology 60(3): 489-495
1985
ISSN/ISBN: 0009-9104 PMID: 4017286 Document Number: 255960
Hemolytic activities of the classical and alternative complement pathways and levels of C1, C4, C3, factor B and C1 inhibitor (C1-INH) were measured in 85 serum samples from 46 patients with chronic lymphocytic leukemia (CLL). Significantly decreased mean C1 and C4 levels were found; the hemolytic activities of these components were low or below normal in > 50% of the sera tested. In 15 sera from 5 patients a complement profile characteristic of acquired C1-IHN deficiency was observed. The depression of the activity of the classical complement pathway apparently is a frequently occurring feature in CLL.