Changes in canine intrahepatic blood flow distribution under inhalational anesthetics
Hasegawa, K.; Iijima, K.; Oka, T.; Yonezawa, T.
Masui. Japanese Journal of Anesthesiology 34(5): 619-625
1985
ISSN/ISBN: 0021-4892 PMID: 4032690 Document Number: 255573
Most studies on hepatic hemodynamics under anesthesia have been carried out by means of the dilution method using dye or labeled isotopes. The dilution method is unable to simultaneously show changes in hepatic arterial (FHA) and portal venous blood flow (FPV). FHA and FPV were measured using the electromagnetic method and hepatic tissue blood flow (FT) was determined by the thermoelectrical method under halothane (1.0%, 1.5%), enflurane (1.5%, 2.0%) and ether (3.0%, 5.0%) anesthesia in mongrel dogs, respectively. Under halothane anesthesia (1.5%, 60 min), FHA decreased to 58% of the control value with a parallel reduction in systemic blood pressure, and both FHA and FT fell to 70% of the control. The administration of enflurane (2.0%, 60 min) made reductions in FHA, FPV and FT to 48%, 74% and 74% of the control values respectively. Ether anesthesia (5.0%, 60 min) was associated with a reduction in FHA and slight falls in FPV and FT, which were not paralleled by a decrease in blood pressure. Evidently, there is a close relation between the changes in hepatic blood flow (FHA, FPV, FT) and arterial blood pressure under halothane and enflurane anesthesia, while hepatic blood flow is independent on arterial blood pressure during ether anesthesia. The change in FT was independent of FHA alone and of FPV alone, but not to the sum of FHA and FPV under inhalational anesthesia.