Interrelation of the intracellular oxidation-reduction processes and the organic water balance in experimental peritonitis in rats
Gubskiĭ, V.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 99(6): 652-654
1985
ISSN/ISBN: 0365-9615 PMID: 4016252 Document Number: 255449
Dissociation of oxidative phosphorylation and the lowering of the respiratory control during oxidation of succinate, alpha-ketoglutarate and pyruvate by hepatocyte mitochondria were observed in rats with experimental fecal peritonitis. The initial increase in the oxidation rate of the substrates enumerated is replaced by inhibition, whose degree is maximal as regards alpha-ketoglutarate, being less manifest as regards succinate. In the absence of the manifestations of the total dehydration, the increased water content in liver, skeletal muscle and renal tissues is coupled with relatively high values of the ADP/O and is in a good agreement with the lowering of the respiratory control during alpha-ketoglutarate oxidation.