Top Abstract Purchase Related
Home
>
Node
>
Subnode

Therapy of leukemia in rats using a conjugate of specific immunoglobulin and albumin-methotrexate

Storek, J.

Sbornik Lekarsky 87(5): 121-127

1985

ISSN/ISBN: 0036-5327
PMID: 3875893
Document Number: 255220
In order to increase the selectivity of the effect of a cytostatic on a tumor cell, a conjugate of albumin-methotrexate was prepared with specific Ig against antigens of the RT 11 complex which was present on the surface of cells of leukemia KPH-LwI (detected in the inbred LEW tribe). After inoculation of leukemia KPH-LwI the resultant conjugate was applied to the young of the inbred tribe LEW.1N (congenerous with LEW in the main histocompatibility complex RT 1). The survival span of animals treated by the specific Ig and albumin-methotrexate conjugate was compared with that of animals untreated, treated by methotrexate alone and those treated by a conjugate of nonspecific Ig and albumin-methotrexate. While methotrexate alone significantly prolonged the survival period of the young, the conjugate of specific Ig with albumin-methotrexate had no leukemostatic effect.

Document emailed within 1 workday
Secure & encrypted payments

Deckert, P.M.; Bornmann, W.G.; Ritter, G.; Williams, C.; Franke, J.; Keilholz, U.; Thiel, E.; Old, L.J.; Bertino, J.R.; Welt, S. 2004: Specific tumour localisation of a huA33 antibody--carboxypeptidase a conjugate and activation of methotrexate-phenylalanine International Journal of Oncology 24(5): 1289-1295
Kovalev, I.E.; Zvartau, E.E.; Lavretskaia, E.F.; Metkalova, S.E.; Basharova, L.A. 1981: Effect of active immunization of rats with a bovine serum albumin-morphine conjugate on morphine consumption Farmakologiia i Toksikologiia 44(2): 200-204
Ellison, R.R.; Hoogstraten, B.; Holland, J.F.; Levy, R.N.; Lee, S.L.; Silver, R.T.; Leone, L.A.; Cooper, T.; Oberfield, R.A.; Ten Pas, A.; Blom, J.; Jacquillat, C.; Haurani, F. 1972: Intermittent therapy with 6-mercaptopurine (NSC-755) and methotrexate (NSC-740) given intravenously to adults with acute leukemia Cancer ChemoTherapy Reports 56(4): 535-542
Komatsu, K. 1990: Effect of high-dose methotrexate on cerebral metabolic rate of glucose in rats and children with acute lymphoblastic leukemia No to Hattatsu 22(5): 477-482
Gottlieb, J.A.; Serpick, A.A. 1970: Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors Cancer Research 30(8): 2132-2138
Kinahan, J.J.; Otten, M.; Grindey, G.B. 1979: Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine Cancer Research 39(9): 3531-3539
Konarev, A.V. 1978: Electrophoretic and immunochemical properties of albumin 0.19 and the specific albumin of soft wheat Biokhimiia 43(4): 621-625
Fujimoto, T.; Sasaki, K.; Goya, N. 1978: Maintenance therapy of intermittent high-dose methotrexate in acute childhood leukemia--4-year survivals Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 41(4): 810-812
Papayan, G.V.; Chefu, S.G.; Petrishchev, N.N.; Iliin, A.A.; Akopov, A.L. 2016: Possibility of the use of the conjugate of indocyanine green with albumin for infrared fluorescent diagnosis of pathological processes in experiment Voprosy Onkologii 62(6): 839-844
Kuanbaev, D.N.; Chimirov, O.B.; Temiralieva, G.A.; Lukhnova, L.I.; Tursunov, A.N. 1990: An immunoglobulin-penicillinase conjugate for detecting the antigen of the causative agent of tularemia Laboratornoe Delo 1: 44-46
Zhang, Y.J.; Wang, N.Q.; Liu, T.; Dong, Z.W. 1990: The antitumor activity of bovine serum albumin-mediated conjugate of hematoporphyrin derivative with antigastric cancer monoclonal antibody Yao Xue Xue Bao 25(12): 886-890
Cadman, E.C.; Glick, J.H.; Cross, J.; Horton, J.; Taylor, S.G. 1984: Sequential methotrexate and 5-FU in CMFP (cyclophosphamide, methotrexate, 5-FU, and prednisone) therapy for breast cancer Cancer Treatment Reports 68(6): 877-879
Iqbal, M.P.; Malik, I.; Mehboobali, N. 1992: Appearance of a methotrexate binding plasma protein during high dose methotrexate therapy JPMA. Journal of the Pakistan Medical Association 42(8): 193-196
Ringdén, O.; Labopin, M.; Gluckman, E.; Reiffers, J.; Vernant, J.P.; Jouet, J.P.; Harrousseau, J.L.; Fiere, D.; Bacigalupo, A.; Frassoni, F.; Gorin, N.C. 1996: Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin a combined with methotrexate as prophylaxis. Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation Bone Marrow Transplantation 18(5): 921-929
Rochas, M.A.; Tufenkji, A.E.; Levillain, P.; Houin, G. 1991: Protein binding of methotrexate to human albumin and serum. a first derivative spectroscopic analysis Arzneimittel-Forschung 41(12): 1286-1288
Holmes, S.J.; Lucas, A.H.; Osterholm, M.T.; Froeschle, J.E.; Granoff, D.M. 1991: Immunoglobulin deficiency and idiotype expression in children developing Haemophilus influenzae type b disease after vaccination with conjugate vaccine. the Collaborative Study Group JAMA 266(14): 1960-1965
Alfonso, J.; Gralla, J.; Klem, P.; Chan, L.; Wiseman, A.C.; Cooper, J.E. 2014: High-Dose Intravenous Immunoglobulin Therapy for Donor Specific Antibodies in Kidney Transplant Recipients with Acute and Chronic Graft Dysfunction: Updates on Previously Reported Cohorts Clinical Transplants 2014: 161-170
Nara, N.; Jinnai, I.; Bessho, M.; Hirashima, K. 1984: Effect of combination therapy of specific active immunization and aclacinomycin-A on murine myeloid leukemia Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 47(6): 1280-1286
Volina, E.G.; Ivanov, A.P.; Kiktenko, V.S.; Tkachenko, E.A.; Arutiunova, G.A. 1986: The use of direct immunoenzyme analysis with genus-specific peroxidase conjugate in leptospirosis Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 72-75
Kosenkova, I.A.; Shatskaia, T.L.; Gavriuchenkova, L.P. 1995: Analysis of the composition of therapeutic preparations of immunoglobulin and albumin using chromatography on biochrome H-70 Gematologiia i transfuziologiia 40(5): 39-41