Influence of H2 receptors blockade upon some central effects of prostacyclin in rats
Brus, R.; Krzemiński, T.; Juraszczyk, Z.; Kurcok, A.; Felińska, W.
Polish Journal of Pharmacology and Pharmacy 37(6): 831-839
1985
ISSN/ISBN: 0301-0244 PMID: 2870486 Document Number: 254947
Prostacyclin (PGI2) administered icv into the lateral rat brain ventricle in a dose of 1 and 10 micrograms caused hypothermia and catalepsy. Joint administration of PGI2 and chlorpromazine produced a greater cataleptic effect than that observed after the neuroleptic alone. Cimetidine (CMT) 2 g/kg po administered 60 min before PGI2 icv injection inhibited hypothermic and cataleptogenic action of PGI2. CMT blocked the cataleptogenic effect of chlorpromazine as well as combination of it with PGI2. CMT inhibited cataleptogenic effect of haloperidol, but it did not block the catalepsy induced by joint administration of haloperidol and PGI2. PGI2 did not change concentration of noradrenaline and dopamine in different brain areas. The results indicate that H2 receptors take part in some central pharmacological effects of PGI2 in rats.