Oral papillomatosis in New Zealand white rabbits
Sundberg, J.P.; Junge, R.E.; el Shazly, M.O.
American Journal of Veterinary Research 46(3): 664-668
1985
ISSN/ISBN: 0002-9645 PMID: 2581486 Document Number: 254671
Oral papillomas were seen in 31% of New Zealand white rabbits (n = 51) examined from 2 local sources. Papillomavirus structural antigens were detected by the peroxidase-antiperoxidase technique in cells of the stratum spinosum which contained basophilic intranuclear inclusions. Homogenates of papillomas hemagglutinated mouse red blood cells and also induced papillomas on the ventral surface of tongues, but not bulbar conjunctiva or vulva, of susceptible rabbits. The same oral papilloma homogenate induced fibromas in neonatal hamsters. Homogenates of hamster fibromas did not cause lesions on tongues of susceptible rabbits.