Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma
Suen, K.C.; Magee, J.F.; Halparin, L.S.; Chan, N.H.; Greene, C.A.
Acta Cytologica 29(5): 867-872
1985
ISSN/ISBN: 0001-5547 PMID: 2996274 Document Number: 254595
The major cytologic features seen in fine needle aspirates from two cases of fibrolamellar hepatocellular carcinoma were: (1) liverlike tumor cells, characterized by plump, polygonal forms with eosinophilic, granular cytoplasm; (2) large oval nuclei with extremely prominent solitary nucleoli; and (3) parallel bands of fibrous tissue and fibrocytes seen within the tumor fragments. Other helpful features included intracytoplasmic hyaline globules and well-delineated pale bodies. Clinically, the tumors occurred in young patients with noncirrhotic livers and ran a more favorable course than do other types of hepatocellular carcinoma.