Sources of variability in dose response platelet aggregometry
Vickers, M.V.; Thompson, S.G.
Thrombosis and Haemostasis 53(2): 219-220
1985
ISSN/ISBN: 0340-6245 PMID: 4024032 Document Number: 253792
An experiment designed to assess the components of variability of a number of measures of (the estimated dose of ADP at which primary aggregation occurs at half its maximum velocity) had the least method error of any of the parameters measured, but that none had a very high between-person component of variability. A simultaneous comparison of a syringe technique and a free-flowing technique for venepuncture revealed no differential effects on the aggregation parameters measured. An enforced increase in the stirring speed in the aggregometer led to an experiment which showed that such a change did not apparently affect the ED50s.