Interferon-inducing and antiviral effects of inosiplex in combination with high-molecular interferon inducers
Tazulakhova, E.B.; Amitina, N.N.; Ershov, F.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 100(10): 457-459
1985
ISSN/ISBN: 0365-9615 PMID: 2413924 Document Number: 251539
It has been shown that the immunostimulant inosiplex (IP) is capable of inducing interferon production in mice and of stimulating interferon induction by high-molecular inducers. The combined use of IP and poly (G)-poly (C) or dsRNA (RFf2) leads to a longer interferon circulation in the blood. All the combination schemes ensuring the effect of interferon production prolongation were tested for anti-viral activity. The prophylactic administration of the drugs permitted the attainment in mice of the increased resistance to experimental influenza.