The immediate and late results of protecting the patient's normal tissues by using the gas hypoxic mixture GHM-10 in the radiation therapy of breast cancer
Strelkov, R.B.; Mardynskiĭ, I.S.; Zakoshchikov, K.F.; Firsova, P.P.
Voprosy Onkologii 31(12): 35-39
1985
ISSN/ISBN: 0507-3758 PMID: 4082505 Document Number: 251443
The effect of inhalation of gaseous hypoxic mixture GHM-10 (oxygen--10 +/- 1.0 and nitrogen--90.0 +/- 1.0%) on radiation response of normal tissues was studied in 184 breast cancer patients. The mixture was administered to 120 patients while 74 controls received a standard course of radiotherapy. Administration of the mixture improved normal tissue resistance to radiotherapy for breast cancer and was followed by lower incidence of long-term radiation injury, lower frequency and shorter duration of general vegetative reactions to radiation.