Acute erythroblastopenia disclosing homozygous beta-thalassemia. Role of parvovirus infection
Leblanc, A.; Gerardin, J.; Girot, R.; Courouce, A.M.; Guillien, F.; Bamberger, J.
Presse Medicale 14(33): 1743-1745
1985
ISSN/ISBN: 0755-4982 PMID: 2999753 Document Number: 251352
An acute, transient aplastic crisis in a 15-month old boy revealed the presence of homozygous beta-thalassaemia. The crisis was very likely due to a parvovirus infection, in view of the presence of specific IgM at the onset and of seroconversion to total antibodies. Later, requirements for transfusions were in favour of an intermediate type thalassaemia. The responsibility of the parvovirus is discussed in the light of recent data concerning the inhibitory action of this virus on bone marrow erythropoiesis.
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