Distribution of 64copper in the blood and different tissues of mice bearing induced fibrosarcoma
Chakravarty, P.K.; Ghosh, A.; Chowdhury, J.R.
Neoplasma 32(5): 553-559
1985
ISSN/ISBN: 0028-2685 PMID: 4069290 Document Number: 250422
To understand the nature of copper distribution during malignancy, 27 strains A/RB mice with fibrosarcoma were used. Tracer methodology with radioactive isotope of copper (64Cu) was applied. In the study made at different time intervals after isotope administration whole blood plasma and different tissues like liver, heart, spleen kidney and brain were investigated. Liver nuclear fractions were also examined. Distribution of 64Cu in different tissues reflected interesting results. While the incorporation pattern in the liver showed gradual fall from 8 h of isotope administration, the tumor tissue exhibited gradual elevation, compared to the controls. The effect of this finding is discussed.