Somatic cell mutants with altered receptor and endocytosis activities
Kuwano, M.; Tomita, K.; Kuratomi, Y.; Yamato, H.; Masuda, A.; Ono, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 12(3 Part 2): 669-676
1985
ISSN/ISBN: 0385-0684 PMID: 2985001 Document Number: 249249
Binding and endocytosis are responsible for cellular uptake of a wide variety of physiologically active ligands. We have selected somatic cell mutants with altered endocytosis activity for low-density lipoprotein, insulin, and epidermal growth factor. Of these mutants, the one with altered response to epidermal growth factor shows aberrant growth behavior in soft agar.