Loop diuretics bind to distinct receptors in renal medulla and cortex
Giesen-Crouse, E.; Fandeleur, P.; Schmidt, M.; Schwartz, J.; Imbs, J.L.
Journal of Hypertension. Suppl Official Journal of the International Society of Hypertension 3(3): S211-S213
1985
ISSN/ISBN: 0952-1178 PMID: 2856706 Document Number: 247917
Receptors which bind [3H]-piretanide were demonstrated on membranes prepared from renal medulla and cortex. They exhibit all the characteristics of a specific receptor such as high affinity, specificity, tissue selectivity, reversible binding kinetics and proportionality between affinity and diuretic effect. Medullary and cortical receptors are clearly distinct since they have different ion requirements.