The induction by 224Ra of myeloid leukaemia and osteosarcoma in male CBA mice
Humphreys, E.R.; Loutit, J.F.; Major, I.R.; Stones, V.A.
International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 47(3): 239-247
1985
ISSN/ISBN: 0020-7616 PMID: 3872276 Document Number: 247601
Radium-224 was injected into 12-week-old male CBA mice in the range 2-64 kBq per mouse either as a single injection or as eight injections spaced at 3.5 day intervals over 4 weeks. Small but significant yields of myeloid leukaemia or osteosarcoma were obtained in all but the control groups. An effect of mode of administration (single or multiple injections) could not be demonstrated but the combined results showed: a maximum yield of myeloid leukaemia in the region 8-16 kBq 224Ra; a greater yield of osteosarcoma than myeloid leukaemia at 64 kBq 224 Ra injected.