Platelet function in surgical stress
Naesh, O.; Friis, J.T.; Hindberg, I.; Winther, K.
Thrombosis and Haemostasis 54(4): 849-852
1985
ISSN/ISBN: 0340-6245 PMID: 2935969 Document Number: 247380
Ten patients for elective cholecystectomy were studied pre-, per- and postoperatively. All had neurolept anesthesia. Plasma concentrations of .beta.-TG, TXB2 and 5-HT and intraplatelet 5-HT were measured. Aggregation to ADP was recorded. Serum cortisol concentration was used as an index of the stress response, showing preoperative increase and postoperative decrease. Closely related to this we observed a significant increase in P--.beta.-TG and P-TXB2 with postoperative normalization in 6 patients without complications. P--5-HT had a peak peroperatively and remained elevated postoperatively. A negative correlation between P--5-HT and decreasing intraplatelet 5-HT postoperatively was observed. High postoperative levels of P--5-HT seem to be related to low arterial PO2 and pulmonary dysfunction. In 3 patients with complications a second increase in P--.beta.-TG, P-TXB2 and partly in P--5-HT was found. Platelets were temporarily refractory to ADP immediately following surgery and showed increased aggregability postoperatively. We conclude that platelets are activated in surgical stress.